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Jessica Sam

As seen in: Cell Press
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Articles by Jessica Sam

TETs Regulate Proepicardial Cell Migration through Extracellular Matrix Organization during Zebrafish Cardiogenesis

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By Heng Pan, Jessica Sam, Yahui Lan, Kelly M. Banks
| Cell Press Verified
Highlights • Zebrafish larvae lacking Tet2 and Tet3 fail in AVC and epicardium development • Inhbaa (in endocardium) and Sox9b (in myocardium) are targets of Tet2/3 demethylation • These genes help coordinate ECM needed by epicardial progenitors Summary Ten-eleven translocation (Tet) enzymes (Tet1/2/3) mediate 5-methylcytosine (5mC) hydroxylation, which can facilitate DNA demethylation and thereby impact gene expression.
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The GCN2-ATF4 Signaling Pathway Induces 4E-BP to Bias Translation and Boost Antimicrobial Peptide Synthesis in Response to Bacterial Infection

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By Nicholas Clark, Deepika Vasudevan, Jessica Sam, Victoria C. Cotham
| Cell Press Verified
4e-bp Is Transcriptionally Induced by ATF4 during Infection in the Fat Body and Gut   Levels of AMP Proteins, but Not Transcripts, Are Reduced in 4e-bp Mutants   The 5? UTRs of Drosomycin, Attacin A, and 4e-bp Support Cap-Independent Translation Much research has focused on the transcriptional response to infection mediated by the innate immune response pathways (Buchon et al., 2014xImmunity in Drosophila melanogaster—from microbial recognition to whole-organism physiology.
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