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Jessica Schreiter

As seen in: The Journal of Biological Chemistry
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Articles by Jessica Schreiter

Human interferon-ϵ and interferon-κ exhibit low potency and low affinity for cell-surface IFNAR and the poxvirus antagonist B18R

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By Bethany Harris Verified, Jessica Schreiter, Marc Chevrier, Jarrat L. Jordan
| The Journal of Biological Chemistry Verified
IFNϵ and IFNκ are interferons that induce microbial immunity at mucosal surfaces and in the skin. They are members of the type-I interferon (IFN) family, which consists of 16 different IFNs, that all signal through the common IFNAR1/IFNAR2 receptor complex. Although IFNϵ and IFNκ have unique expression and functional properties, their biophysical properties have not been extensively studied.
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Human Interferon-ε and interferon-κ exhibit low potency and low affinity for cell surface IFNAR and the poxvirus antagonist B18R

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By Bethany Harris Verified, Jessica Schreiter, Marc Chevrier, Jarrat L. Jordan
| The Journal of Biological Chemistry Verified
IFNє and IFNκ are interferons that induce microbial immunity at mucosal surfaces and in the skin. They are members of the type-I IFN family, which consists of 16 different IFNs, that all signal through the common IFNAR1/IFNAR2 receptor complex. Although IFNє and IFNκ have unique expression and functional properties, their biophysical properties have not been extensively studied. In this report, we describe the expression, purification, and characterization of recombinant human IFNє and IFNκ.
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