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Jethro S Johnson on Muck Rack

Jethro S Johnson

As seen in: MDPI, BioRxiv, MedPage Today, Diabetes Magazine, Journal of Endocrinology
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Articles

Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease

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By Xin Zhou, Xiaotao Shen, Jethro S Johnson, Daniel J Spakowicz
| BioRxiv
Abstract To understand dynamic interplay between the human microbiome and host during health and disease, we analyzed the microbial composition, temporal dynamics, and associations with host multi-omics, immune and clinical markers of microbiomes from four body sites in 86 participants over six years. We found that microbiome stability and individuality are body-site-specific and heavily influenced by the host.
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Role of Oxylipins in the Inflammatory-Related Diseases NAFLD, Obesity, and Type 2 Diabetes

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By Jethro S Johnson, James Mccullagh, Mariya Misheva
| MDPI
Abstract : Oxygenated polyunsaturated fatty acids (oxylipins) are bioactive molecules established as important mediators during inflammation. Different classes of oxylipins have been found to have opposite effects, e.g., pro-inflammatory prostaglandins and anti-inflammatory resolvins. Production of the different classes of oxylipins occurs during distinct stages of development and resolution of inflammation.
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Longitudinal Analysis of Serum Cytokine Levels and Gut Microbial Abundance Links IL-17/IL-22 With Clostridia and Insulin Sensitivity in Humans

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By Xin Zhou, Jethro S Johnson, Daniel J Spakowicz, Wenyu Zhou
| Diabetes Magazine Verified
Genetics/Genomes/Proteomics/Metabolomics Abstract Recent studies using mouse models suggest that interaction between the gut microbiome and IL-17/IL-22–producing cells plays a role in the development of metabolic diseases. We investigated this relationship in humans using data from the prediabetes study of the Integrated Human Microbiome Project (iHMP).
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