Jhommara Bautista

and , “The Temporal Architecture of Human Cells: Organelle Clocks and Distributed Circadian Time.” BioEssays48, no. 6 (2026): e70157. https://doi.org/10.1002/bies.70157 Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.

Abstract Mitochondria are increasingly recognized as master regulators of aging, integrating bioenergetics, redox control, stem cell fate, and innate immune signaling. This review synthesizes evidence that mitochondrial dysfunction is not only a hallmark but also an upstream driver of stem cell exhaustion and inflammaging.

Abstract Circadian rhythms shape antitumor immunity by regulating endocrine signaling, vascular permissiveness, leukocyte trafficking, metabolism, and suppressive features of the tumor microenvironment across the 24-h cycle. Here, we propose that biological time may represent an important design variable for CAR T-cell therapy.