Ji-Hao Zhou

Keywords leukemia metabolism SLC25A51 OGDH complex NAD+ Get full text access Log in, subscribe or purchase for full access. References 1. DiNardo, C.D. ∙ Cortes, J.E. Mutations in AML: prognostic and therapeutic implications Hematology Am. Soc. Hematol. Educ. Program. 2016; 2016:348-355 2. Patel, J.P. ∙ Gönen, M. ∙ Figueroa, M.E. ... Prognostic relevance of integrated genetic profiling in acute myeloid leukemia N. Engl. J. Med. 2012; 366:1079-1089 3. Papaemmanuil, E. ∙ Gerstung, M. ∙ Bullinger, L. ...

Abstract Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia defined by the t(15;17)(q24;q21)-derived PML::RARA fusion. However, a small subset of patients harbor cryptic or atypical RARA rearrangements that escape detection by routine real-time quantitative RT-PCR (qRT-PCR). We report a 34-year-old man presenting typical APL in whom repeated testing for the canonical long, short, and variant PML::RARA transcripts yielded negative results.