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Articles by Ji She
Structural Mechanism of EMRE-Dependent Gating of the Human Mitochondrial Calcium Uniporter
Highlights • Human MCU is a tetrameric channel with one EMRE bound to each MCU subunit • EMRE stabilizes the juxtamembrane loop of MCU, conferring EMRE-dependent gating to MCU • EMRE triggers dimerization of two MCU-EMRE complexes at MCU’s N-terminal domains Summary Mitochondrial calcium uptake is crucial to the regulation of eukaryotic Ca 2+ homeostasis and is mediated by the mitochondrial calcium uniporter (MCU).
Discrete-Event Simulation of Ground-Based Timber Harvesting Operations
Operational studies are necessary to support production and management decisions of forest industries. A time study (TS) approach is widely used in timber harvesting operations to understand the performance of individual harvesting machines as well as the entire system. However, several limitations of the TS approach include the use of generalized utilization rates, incapability of capturing interactions among equipment, and model extrapolation in sensitivity analysis.
Structures of the calcium-activated, non-selective cation channel TRPM4
TRPM4 is a calcium-activated, phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P ) -modulated, non-selective cation channel that belongs to the family of melastatin-related transient receptor potential (TRPM) channels. Here we present the electron cryo-microscopy structures of the mouse TRPM4 channel with and without ATP. TRPM4 consists of multiple transmembrane and cytosolic domains, which assemble into a three-tiered architecture.
Structure of mammalian endolysosomal TRPML1 channel in nanodiscs
The mucolipin subfamily of transient receptor potential (TRPML) channels are predominantly localized in the membranes of the late endosomes and lysosomes1, 2. Among the three isoforms of TRPML channels (TRPML1–3), TRPML1 is ubiquitously expressed in mammalian cells and has been the subject of extensive study2, 9, 10, 11, 12, 13, 14.
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