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Jia Shen Sio

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Articles

A Phase-Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease-Associated Protein Aggregation and Guides Suppressor Design

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By Hui Xuan Lim, Huitao Liu, Jia Shen Sio
| Wiley Online Library Verified
1 Introduction Proteostasis depends on the reliable folding of polypeptides into native conformations that are sufficiently stable to resist off-pathway self-association, yet this balance is frequently disrupted in neurodegenerative diseases [1, 2]. In disorders such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia, tauopathies, and prion disease, metastable proteins can traverse rugged energy landscapes and convert into highly ordered amyloid assemblies.
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