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Tumor molecular age acceleration is associated with early progression in diffuse large B-cell lymphoma
Around 40% of diffuse large B-cell lymphoma (DLBCL) patients develop primary refractory or relapsed disease after receiving rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) [1]. Patients who experience progression of disease within 24 months (POD24) have particularly dismal prognosis with a median overall survival (OS) of around 7 months after progression [2].
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