Jia-Ying Fu

Abstract Family caregivers often experience anxiety and depression. Technology-based Acceptance and Commitment Therapy (technology-based ACT) provides new treatment options, but its effectiveness for family caregivers needs further research. To explore the effectiveness of technology-based ACT in relieving family caregivers’ anxiety and depression symptoms. Search databases of PubMed, Web of Science, Cochrane Library, CINAHL, and Embase from inception to January 6, 2026.

Abstract Although oxaliplatin is widely used in the frontline treatment of colorectal cancer (CRC), CRC recurrence is commonly observed owing to oxaliplatin resistance. The roles of long non-coding RNAs-encoded microproteins in oxaliplatin chemoresistance remain inadequately explored. In this study, a CRISPR/Cas9 library was developed to target previously identified 314 microproteins translated from long non-coding RNAs, followed by functional screening.

1 Introduction Colorectal cancer (CRC) is one of the most common malignant tumors with poor overall survival, having the incidence and mortality respectively ranking 3rd and 2nd worldwide.[1] Failure of radiotherapy and chemotherapy is the main cause of poor prognosis in cancer patients, and radiation and chemical agents damage both cancer and normal cells, leading to serious adverse effects.