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Selective inhibition of monoamine oxidase B represents a therapeutic strategy for diabetic peripheral neuropathy
Abstract Diabetic peripheral neuropathy (DPN), a severe complication of diabetes, is a key risk factor for diabetic foot (DF) that contributes highly to amputation and mortality. The pathogenesis of DPN remains unclear and complex, with no effective treatments currently available. Monoamine oxidase (MAO), a flavin adenine dinucleotide (FAD)-dependent enzyme, catalyzes the oxidative deamination of critical biogenic amines.
Dynamics of IS1071 and Its Accessory Gene Functions During Start‐Up of an On‐Farm Biopurification System
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description emi70120-sup-0001-supinfo.docxWord 2007 document , 2.5 MB Data S1. Supporting Information. emi70120-sup-0002-supinfo.xlsxExcel 2007 spreadsheet , 3 MB Data S2. Supporting Information. References , , , et al. 2020. “CARD 2020: Antibiotic Resistome Surveillance With the Comprehensive Antibiotic Resistance Database.” Nucleic Acids Research 48, no. D1: D517–D525. , , , and . 2011.
The Pharmacokinetics, Pharmacodynamics, Tolerability, and Safety of Orally Dosed QY201, a Novel JAK1/TYK2 Inhibitor, in Chinese Healthy Subjects
Conflicts of Interest All authors declare no competing interests. Supporting Information Filename Description jcph70053-sup-0001-SuppMat.docx12.9 MB Supporting Information References 1, , , , , . JAK inhibition as a therapeutic strategy for immune and inflammatory diseases. Nat Rev Drug Discov. 2017; 16(12): 843-862. 2, , , . The regulation of JAKs in cytokine signaling and its breakdown in disease. Cytokine. 2019; 118: 48-63. 3, , , et al.
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