Jiabeini Zhang

Abstract Although injectable respiratory syncytial virus (RSV) pre-F vaccines are clinically established, effective intranasal alternatives remain elusive. Geometric and surface antigen display properties are critical for respiratory B cell activation, yet lack strategies for systematic optimization. Here we report a library of DNA nanocarriers with controlled dimensions and sizes, aiming to systemically evaluate the influence of geometric properties on intranasal retention.

1 Introduction Cancer remains one of the leading global health challenges, with incidence and mortality continuing to rise worldwide. Despite advances in surgery, chemotherapy, radiotherapy, and targeted therapies, treatment outcomes for metastatic, immune-evasive, and therapy-resistant tumors remain unsatisfactory, often accompanied by recurrence and systemic toxicity [1].