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Jiajia Ying on Muck Rack

Jiajia Ying

As seen in: Nature, Wiley Online Library, Frontiers
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Articles

Zona incerta somatostatin + neurons modulate seizure progression through hypothalamic circuits

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By Mengdi Zhang, Lin Yang, Yuan Zhou, Yeping Ruan, Dongxiao Jiang, Lilong Yu, Jiajia Ying, Wenjing Wang, Tianyu Tang, Menghan Li, Zhong Chen, Fan Fei, Cenglin Xu, Yi Wang
| Nature Verified
Abstract GABAergic neurons critically regulate epileptic seizures, yet circuit mechanisms mediated by subtype-specific GABAergic neurons in the zona incerta (ZI) remain unclear. Here we reveal the essential role of ZI somatostatin+ GABAergic neurons in seizure modulation in the mouse hippocampal kindling model. In vivo Ca2+ fiber photometry and optogenetics show that ZI GABAergic neurons are gradually activated during seizure progression.
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Neonatal bronchopulmonary dysplasia severity and respiratory outcomes at 3 years of age: a prospective cohort study

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By Jiajia Ying, Jingqian Zhou, Hongfang Chen, Jian Zhou
| Frontiers
Abstract Objective: To examine whether bronchopulmonary dysplasia (BPD) severity is associated with pulmonary function abnormalities and asthma diagnosis risk at 3 years of age, and to support risk-stratified respiratory follow-up in children with BPD. Methods: This prospective cohort study included 68 preterm infants admitted to the neonatal intensive care unit of The First People's Hospital of Yongkang between January 2022 and December 2022.
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Bridging hydrogen-bond-stabilized polymeric coacervate core micelles for high-efficiency drug encapsulation and delivery

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By Jiafeng Wang, Jiajia Ying, Jianxiang Huang, Longchen Zhu, Hang Yang, Junjun Li, Zimeng Liu, Yongli Mu, Changhuo Xu, Kefeng Ding, Xin Zhang, Tianhua Zhou, Xiangrui Liu, Youqing Shen, Quan Zhou
| Nature Verified
Abstract Polymeric nanoparticles represent one of the most promising classes of non-lipid-based drug delivery vehicles. However, their clinical translation remains limited by poor drug loading capacity and suboptimal delivery efficiency. We here develop one type of polymeric nanoparticles, referred to as PCCMs (Polymeric Coacervate Core Micelles), which are assembled from a sulfoxide-containing block polymer.
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