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Jian-Ming Ying on Muck Rack

Jian-Ming Ying

As seen in: Nature
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Articles

Characterization of the extrinsic and intrinsic signatures and therapeutic vulnerability of small cell lung cancers - Signal Transduction and Targeted Therapy

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By Zheng Wang, Ming-Kun Li, Jian-Ming Ying, Chong Chen, Hong-Bin Ji
| Nature Verified
Abstract Small-cell lung cancer (SCLC), an aggressive neuroendocrine tumor strongly associated with exposure to tobacco carcinogens, is characterized by early dissemination and dismal prognosis with a five-year overall survival of less than 7%. High-frequency gain-of-function mutations in oncogenes are rarely reported, and intratumor heterogeneity (ITH) remains to be determined in SCLC.
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The prognostic value of tumour-infiltrating lymphocytes, programmed cell death protein-1 and programmed cell death ligand-1 in Stage I-III triple-negative breast cancer | British Journal of Cancer

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By Shu-Nan Qi, Ye-Xiong Li, Guang-Yi Sun, Jian-Ming Ying
| Nature Verified
Abstract Background Tumour-infiltrating lymphocytes (TILs) represent a robust biological prognostic biomarker in triple-negative breast cancer (TNBC); however, the contribution of different subsets of immune cells is unclear. We investigated the prognostic value of immune markers, including stromal TILs (sTILs), CD8+T and FOPX3+T cells, PD-1 and PD-L1 in non-metastatic TNBC. Methods In total, 259 patients with Stage I–III TNBC were reviewed.
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