Jiane Liu

1 Introduction Osteoarthritis (OA) has become one of the most common diseases, affecting more than 500 million people worldwide [1]. This chronic degenerative disease compromises the entire synovial joint with key features of articular cartilage destruction, synovial inflammation, subchondral bone remodelling, osteophyte formation, joint space narrowing and tendons and ligaments instability [2, 3]. In severe cases, OA can lead to functional disability, severely diminishing the quality of life [4].

CONFLICT OF INTEREST STATEMENT The authors declare that there is no conflict of interest. REFERENCES 1, , , et al. Regulatory role of KCa3.1 in immune cell function and its emerging association with rheumatoid arthritis. Front Immunol. 2022; 13:997621. 2, , . Cytokine networks in the pathogenesis of rheumatoid arthritis. Int J Mol Sci. 2021; 22(20):10922. 3, , , , . Magnetic resonance imaging-assessed synovial and bone changes in hand and wrist joints of rheumatoid arthritis patients. Korean J Intern Med.