Jiangying Liu
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From fibrotic mechanisms to clinical translation: the drug therapy revolution and delivery system breakthrough in proliferative vitreoretinopathy
1 Introduction Proliferative vitreoretinopathy (PVR) is a blinding eye disease characterized by abnormal scar formation. Following retinal detachment or ocular trauma, damaged retinal pigment epithelial (RPE) cells migrate into the vitreous and interact with glial cells, vitreous cells, macrophages, and fibroblasts to form fibrous membranes (1). This process is termed epithelial-mesenchymal transition (EMT) (2).
Systematic mining and quantification reveal the dominant contribution of non-HLA variations to acute graft-versus-host disease - Cellular & Molecular Immunology
Abstract Human leukocyte antigen (HLA) disparity between donors and recipients is a key determinant triggering intense alloreactivity, leading to a lethal complication, namely, acute graft-versus-host disease (aGVHD), after allogeneic transplantation. Moreover, aGVHD remains a cause of mortality after HLA-matched allogeneic transplantation.
Jag1/2 Maintain Esophageal Homeostasis and Suppress Foregut Tumorigenesis by Restricting the Basal Progenitor Cell Pool
Keywords Animals, Jagged-1 Protein, Homeostasis, Esophageal Neoplasms, Esophagus, Stem Cells, Mice, Jagged-2 Protein, Humans, Carcinogenesis, Esophageal Squamous Cell Carcinoma, Mice, Knockout, Signal Transduction, Carcinoma, Squamous Cell, Receptors, Notch, Cell Differentiation, Male, Female, Differentiation, Cell proliferation, Oesophageal cancer, Adult stem cells Abstract Basal progenitor cells are crucial for maintaining foregut (the esophagus and forestomach) homeostasis.
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