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Jiangzhou Shi

As seen in: Frontiers in Immunology

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Articles

Harnessing Vδ1 + T cells for next-generation immunotherapy: from mechanistic insights to clinical translation

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By Fan Wang, Jiaxuan Zhao, Tongcun Zhang, Jiangzhou Shi
| Frontiers in Immunology
Abstract The unique ability of Vδ1+ T cells to recognize targets in a major histocompatibility complex (MHC)-unrestricted manner makes them promising candidates for immunotherapy. This review explores the biological underpinnings of their advantages, particularly their ability to penetrate and migrate through solid tumors, their antigenic promiscuity, and their functional plasticity in inflammatory tumor microenvironments.
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