Jianming Ying

Abstract Distant metastasis, characterized by organotropism, is a major cause of mortality in lung adenocarcinoma (LUAD). In this study, digital spatial profiling (DSP), multiplex immunofluorescence (mIF), and clinical data from 52 LUAD patients were integrated to develop organ-specific metastasis risk models, and the molecular mechanisms underlying metastatic organotropism were investigated.

Keywords small cell lung cancer lymph node metastasis spatial molecular imaging spatial transcriptomics tumor microenvironment Introduction Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine malignancy that accounts for about 15% of lung cancer cases and is characterized by rapid metastasis and poor prognosis.1 The majority of SCLC patients already have metastatic disease at diagnosis, with lymph nodes (LNs), brain, liver, and bone being common sites of dissemination.2...

Abstract Neoadjuvant combined immunotherapy has provided more treatment options for patients with gastric adenocarcinoma (GA). However, some GA patients, especially those with primitive enterocyte phenotype (GAPEP) show a poor response to immunotherapy, even with positive PD-L1 expression. We enrolled multiple cohorts from our center and utilized public data to identify the predictive factors and explore the immunosuppressive features of GAPEP by multi-omics methods.