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Jianxian Luo on Muck Rack

Jianxian Luo

As seen in: BioRxiv, eLife
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Articles

14-3-3 protein augments the protein stability of phosphorylated spastin and promotes the recovery of spinal cord injury through its agonist intervention

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By Qiuling Liu, Hua Yang, Jianxian Luo, Cheng Peng
| eLife
eLife assessment The finding that Fusicoccin (FC-A) promotes locomotor recovery after spinal cord injury is useful and is supported by solid data, and the idea of harnessing small molecules that may affect protein-protein interactions to promote axon regeneration is valuable. The evidence showing that 14-3-3 and spastin interact and that 14-3-3 enhances spastin function and stability in cells is solid.
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14-3-3 protein augments the protein stability of phosphorylated spastin and promotes the recovery of spinal cord injury through its agonist intervention

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By Qiuling Liu, Hua Yang, Jianxian Luo, Cheng Peng
| BioRxiv
Abstract Axon regeneration is abortive in the central nervous system following injury. Orchestrating microtubule dynamics has emerged as a promising approach to improve axonal regeneration. The microtubule severing enzyme spastin is essential for axonal development and regeneration through remodeling of microtubule arrangement. To date, however, little is known regarding the mechanisms underlying spastin action in neural regeneration after spinal cord injury.
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The 14-3-3/spastin pathway coordinates neurite regeneration and recovery of spinal cord injury by targeting microtubule dynamics

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By Qiuling Liu, Hua Yang, Cheng Peng, Jianxian Luo
| BioRxiv
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