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Jianyi Yin

As seen in: Nature, Gastrointestinal Endoscopy
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Articles

ARHGEF2 isoform switching couples intestinal epithelial barrier function with autophagic host defense response to pathogens

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By Shuyuan Chen, Alka Diwaker, Lei Guo, Ashutosh Shukla, Mary-Joe Touma, Yassin EL-Najjar, Lin Xu, Jianyi Yin, Ezra Burstein, Marcel Mettlen, Andrew Lemoff, Suraj Patel, Josephine Ni, Abdulmajeed Salamah, Neethu S. Alex, Hans-Christian Reinecker
| Nature Verified
Abstract Intestinal epithelial integrity is essential for host defense, yet how epithelial junctional scaffolds coordinate antimicrobial immunity remains unclear. We show that the long GEF-H1 isoforms (mouse Arhgef2-207; human ARHGEF2-219) localize to adherens junctions in polarized epithelial cells through interactions with actin and Nectin-3, whereas the shorter Arhgef2-201 isoform localizes to tight junctions.
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584 CALCIUM-SENSING RECEPTOR MODULATION AS PRECISION THERAPY FOR GUCY2C GAIN-OF-FUNCTION MUTATIONS

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By Justin Williams, Jason Park, David Willcutts, Justin Williams, Qi Liu, Mihir Ranjan, Jianyi Yin, Daniel Kramer Verified, Baoyu Chen, Ezra Burstein, Jonathan M. Whittamore, Luis F Sifuentes-Dominguez, David Willcutts, Mary-Joe Touma
| Gastrointestinal Endoscopy Verified
Also available on ScienceDirect
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Mechanical Stimuli Affect Escherichia coli Heat-Stable Enterotoxin-Cyclic GMP Signaling in a Human Enteroid Intestine-Chip Model

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By Laxmi Sunuwar, Jianyi Yin, Magdalena Kasendra, Katia Karalis
| asm.org
Molecular Pathogenesis Laxmi Sunuwar, Jianyi Yin, Magdalena Kasendra, Katia Karalis, James Kaper, James Fleckenstein, Mark Donowitz Manuela Raffatellu, Editor DOI: 10.1128/IAI.00866-19 ABSTRACT Modeling host-pathogen interactions with human intestinal epithelia using enteroid monolayers on permeable supports (such as Transwells) represents an alternative to animal studies or use of colon cancer-derived cell lines.
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