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Jianyi Yin

As seen in: Gastrointestinal Endoscopy
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Articles

584 CALCIUM-SENSING RECEPTOR MODULATION AS PRECISION THERAPY FOR GUCY2C GAIN-OF-FUNCTION MUTATIONS

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By Justin Williams, Jason Park, David Willcutts, Justin Williams, Qi Liu, Mihir Ranjan, Jianyi Yin, Daniel Kramer Verified, Baoyu Chen, Ezra Burstein, Jonathan M. Whittamore, Luis F Sifuentes-Dominguez, David Willcutts, Mary-Joe Touma
| Gastrointestinal Endoscopy Verified
Also available on ScienceDirect
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Mechanical Stimuli Affect Escherichia coli Heat-Stable Enterotoxin-Cyclic GMP Signaling in a Human Enteroid Intestine-Chip Model

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By Laxmi Sunuwar, Jianyi Yin, Magdalena Kasendra, Katia Karalis
| asm.org
Molecular Pathogenesis Laxmi Sunuwar, Jianyi Yin, Magdalena Kasendra, Katia Karalis, James Kaper, James Fleckenstein, Mark Donowitz Manuela Raffatellu, Editor DOI: 10.1128/IAI.00866-19 ABSTRACT Modeling host-pathogen interactions with human intestinal epithelia using enteroid monolayers on permeable supports (such as Transwells) represents an alternative to animal studies or use of colon cancer-derived cell lines.
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Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model

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By Magdalena Kasendra, Raymond Luc, Jianyi Yin, Dimitris V Manatakis, Gauri Kulkarni, Carolina Lucchesi, Josiah Sliz, Athanasia Apostolou, Laxmi Sunuwar, Jenifer Obrigewitch, Kyung-Jin Jang, Geraldine Hamilton, Mark Donowitz, Katia Karalis
| eLife
Abstract Induction of intestinal drug metabolizing enzymes can complicate the development of new drugs, owing to the potential to cause drug-drug interactions (DDIs) leading to changes in pharmacokinetics, safety and efficacy. The development of a human-relevant model of the adult intestine that accurately predicts CYP450 induction could help address this challenge as species differences preclude extrapolation from animals.
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