Jianzhang Hu on Muck Rack

Jianzhang Hu

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Oxidative stress imbalance and cellular damage mediated by the ND4 G11778A mutation - Scientific Reports

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By Lijun Fang, Kangyue Fu, Mengyu Yang, Yiwen Xu, Ezeugwu Sussan Ukamaka, Dianbo Qu, Tianwen Huang, Jianzhang Hu
| Nature
Abstract The mechanisms underlying cellular damage induced by the mitochondrially encoded NADH dehydrogenase subunit 4 (MT-ND4) with R340H mutation caused by the variant m.11778G > A in complex I are intricate. Numerous studies indicate that mitochondria play a primary role in cellular death due to this mutation. However, the detailed pathological effects remain incompletely elucidated.
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