Jiayi Mu

Unraveling the time-dependent mechanism of quercetin glycosides from natural green silk in ameliorating UV-induced photoaging Skin photoaging, driven by chronic ultraviolet (UV) exposure, represents a growing global health concern, with epidemiological studies linking cumulative UV exposure to increased skin cancer risk and accelerated aging phenotypes. Quercetin glycosides, such as rutin and isoquercitrin, exhibit superior antioxidant and UV-protective properties.

1 Introduction Unprecedented global temperature increases have led to more frequent, prolonged and severe heat extremes since the Industrial Revolution (Meehl and Tebaldi 2004; Thompson et al. 2022). Heat extremes have significant impacts on society, natural ecosystems and agricultural production, while posing serious effects on public health, particularly for individuals with pre-existing health conditions (Santágata et al. 2017; Gampe et al. 2021).