Jiaying Shi

Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description odi70408-sup-0001-Supinfo.docxWord 2007 document , 2.7 MB Figure S1: (A) t-SNE plot of 18 cell subclusters in mouse mandibular tissue based on Seurat v5 analysis. (B) Dot plot of representative marker genes across lineages.

To the Editor, Allergic diseases have become among the most significant chronic noncommunicable diseases of the 21st century globally. Epidemiological data from China indicate that the total number of patients with asthma has reached more than 40 million, among whom allergic asthma accounts for more than 60%. Notably, approximately 50% of allergic asthma patients also have allergic rhinitis and this co-occurrence has become a common pattern of chronic disease in China [1-3].

1 Introduction Breast cancer (BRCA) is the leading cause of cancer incidence in women worldwide, with its lethality primarily driven by the development of distant metastases [1]. A significant fraction of patients with early-stage disease eventually relapse with incurable metastatic tumors, often years after initial therapy [2].