Jiaying Xing

Abstract Bone dynamically maintains homeostasis through mechanotransduction, a process essential for skeletal integrity and frequently disrupted in disease. Yet how bone cells decode mechanical cues into adaptive responses remains poorly understood. Here, we identify MACF1, a cytoskeletal crosslinker and core component of stress granules (SGs), as a mechanosensitive scaffold that undergoes phase separation via its intrinsically disordered region 2 (IDR2).

Physico-Chemical Treatment and Resource RecoveryAugust 12, 2024 Jiaying Xing State Key Joint Laboratory of Environment Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, P. R. China Jianjun Chen State Key Joint Laboratory of Environment Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, P. R.