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Jiban Barman on Muck Rack

Jiban Barman

As seen in: BioRxiv
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Articles

Drosophila grainyhead gene and its neural stem cell-specific enhancers show epigenetic synchrony in the cells of the central nervous system.

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By Rashmi Sipani, Yamini Rawal, Jiban Barman, Prakeerthi Abburi
| BioRxiv
Abstract Enhancers are the epicentres of tissue-specific gene regulation. In this study, we have used the central nervous system (CNS) specific expression of the Drosophila grainyhead (grh) gene to make a case for deleting the enhancers in a sensitised background of other enhancer deletion, to functionally validate their role in tissue-specific gene regulation.
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Drosophila grainyhead gene and its neuroblast-specific enhancers show epigenetic synchrony in the cells of central nervous system.

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By Rashmi Sipani, Yamini Rawal, Jiban Barman, Prakeerthi Abburi
| BioRxiv
Abstract The enhancers are the epicentre of multicellular gene regulation. Therefore, their role in transcription needs to be functionally validated by deleting them, which will then serve as a central point for understanding the epigenetic/molecular basis of tissue-specific gene regulation.
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