Jiehoon Kwak

Editor’s summary Gliomas with mutations in the gene isocitrate dehydrogenase (IDH) are the most common type of malignant brain tumor in young adults. The IDH mutation has been proposed to occur at an early stage of glioma development, but the precise “cell of origin” has yet to be identified. Park et al. report that glial progenitor cells (GPCs), including oligodendrocyte progenitor cells (OPCs), carry the earliest IDH mutation (see the Perspective by Mount and Suvà).

August 31, 2022 | Ophthalmology | University of Ulsan Purpose: To develop a variational autoencoder (VAE) suitable for analysis of the latent structure of anterior segment optical coherence tomography (AS-OCT) images and to investigate possibilities of latent structure analysis of the AS-OCT images. Methods: We retrospectively collected clinical data and AS-OCT images from 2111 eyes of 1261 participants from the ongoing Asan Glaucoma Progression Study.

Abstract Discovering the cell-of-origin harboring the initial driver mutation provides a fundamental basis for understanding tumor evolution and development of new treatments. For isocitrate dehydrogenase (IDH) mutant gliomas, the most common malignant primary brain tumors in adults under 50, the cell-of-origin remains poorly understood.