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In Mendelian randomization research, genetic information is usually used as an instrumental variable (IV) due to their random distribution in humans and robust associations with the exposure and outcome variables being investigated. EA was assessed causally associated with lung cancer, FEV1, FVC, FEV1/FVC and asthma using two-step Mendelian randomization analysis. All GWAS summary statistics were gathered from a public GWAS website (https://gwas.mrcieu.ac.uk/) for the purposes of these analyses.
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