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Articles by Jieli Lu
Effects of intensive blood pressure control on cardio-kidney outcomes by KDIGO risk categories: a Post Hoc analysis of ACCORD-BP and SPRINT trials
Abstract The effects of intensive systolic blood pressure (SBP) control on cardiovascular (CV) and kidney outcomes across different Kidney Disease Improving Global Outcomes (KDIGO) risk categories remain unclear. We performed a secondary analysis of the Systolic Blood Pressure Intervention Trial (SPRINT) and the SPRINT-eligible Action to Control Cardiovascular Risk in Diabetes Blood Pressure (ACCORD-BP) trial. Participants were categorized into low, moderate, and high/very-high KDIGO risk groups.
Multivariate genome-wide analyses of insulin resistance unravel novel loci and therapeutic targets for cardiometabolic health - Nature Communications
Abstract Limited identification of insulin resistance-associated loci hinders understanding of its role in cardiometabolic health, impeding therapeutic strategies.
How lifestyle, social determinants of health, and sex shape life expectancy in China
Life expectancy is a fundamental metric in public health, yet it captures only mortality, not quality of life. Healthy ageing entails not just longer lives, but ones lived independently and with dignity.
Phenotyping obesity through a two-dimensional tree structure reveals cardiometabolic heterogeneity
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Keywords: heterogeneity obesity diabetes DDRTree cardiovascular disease Introduction With the rapid development of the global economy, significant changes in dietary patterns and lifestyles have led to a widespread prevalence of obesity, which is now recognized as a global health issue.1,2 In China, overweight is defined as a body mass index (BMI) of 24.0–27.9 kg/m2 and obesity as a BMI ≥ 28.0 kg/m2, according to criteria proposed by the Working Group on Obesity in China.3 Based on these...
By Xiaojing Jia, Hong Lin, Yilan Ding, Chunyan Hu, Shuangyuan Wang, Yu Xu, Min Xu, Feiyue Huang, Feixia Shen, Xuejiang Gu, Yiming Mu, Lulu Yilun Chen Verified, Tianshu Zeng, Lixin Shi, Qing Su, Xuefeng Yu, Guijun Qin, Qin Wan, Gang Chen, Xulei Tang, Zhengnan Gao, Ruying Hu, Zuojie Luo, Yingfen Qin, LI YI CHEN, Xinguo Hou, Yanan Huo, qiang li, Guixia Wang, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Yujin Zhu, Tao Yang, Jiajun Zhao, Yifang Zhang, Xingkun Xu, Huapeng Wei, Jie Zheng, Tiange Wang, Guang Ning, Yuhong Chen, Weiqing Wang, Yufang Bi, Jieli Lu
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Cell Reports Medicine
Verified
Revisiting obesity thresholds for cardiovascular disease and mortality risk in Chinese adults: Age- and gender-specific insights
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Keywords obesity cardiovascular disease mortality aging gender differences Introduction Obesity is a major public health challenge globally that has increased substantially in the past four decades. In China, the national prevalence of overweight and obesity among adults, as defined by body mass index (BMI), was estimated at 34.3% and 16.4%, respectively, between 2015 and 2019.
By Xiaojing Jia, Chunyan Hu, Yu Xu, Yue Yin, Hong Lin, Ruizhi Zheng, Min Xu, Tiange Wang, Hong Wei Qiao, Guijun Qin, Yingfen Qin, Xulei Tang, Zhen Ye, Ruying Hu, Lixin Shi, Qing Su, Xuefeng Yu, Qin Wan, Gang Chen, Zhengnan Gao, Guixia Wang, Feixia Shen, Xuejiang Gu, Zuojie Luo, LI YI CHEN, Xinguo Hou, Yanan Huo, qiang li, Yinfei Zhang, Tianshu Zeng, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Donghui Li, Shenghan Lai, Lulu Yilun Chen Verified, Jiajun Zhao, Yiming Mu, Guang Ning, Yuhong Chen, Jieli Lu, Yufang Bi, Weiqing Wang
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Cell Reports Medicine
Verified
Association of Social Determinants, Lifestyle, and Metabolic Factors With Mortality in Chinese Adults: A Nationwide 10-Year Prospective Cohort Study
Abstract Nationwide estimates of the impact of common modifiable risk factors on mortality remain crucial. We aim to assess the influence of social determinants, lifestyle, and metabolic factors on mortality in 174,004 adults aged ≥40 years from the China Cardiometabolic Disease and Cancer Cohort (4C) Study. We reveal that 17 modifiable factors are independently associated with mortality, accounting for 64.8% of all-cause mortality, 77.4% of cardiovascular mortality, and 44.8% of cancer mortality.
Reducing inequity through tackling social determinants of cardiovascular diseases in China
News & Views Reducing inequity...
BCKDH kinase promotes hepatic gluconeogenesis independent of BCKDHA - Cell Death & Disease
Abstract Elevated circulating branched-chain amino acids (BCAAs) are tightly linked to an increased risk in the development of type 2 diabetes mellitus. The rate limiting enzyme of BCAA catabolism branched-chain α-ketoacid dehydrogenase (BCKDH) is phosphorylated at E1α subunit (BCKDHA) by its kinase (BCKDK) and inactivated. Here, the liver-specific BCKDK or BCKDHA knockout mice displayed normal glucose tolerance and insulin sensitivity.
Association of social determinants, lifestyle, and metabolic factors with mortality in Chinese adults: A nationwide 10-year prospective cohort study
Highlights • Cardiovascular disease and cancer account for over 72% of all-cause mortality in China • Modifiable risk factors explain 64.8% of all-cause mortality • Low education emerges as the leading factor for both all-cause and cancer mortality • Hypertension is the predominant factor for cardiovascular mortality Summary Nationwide estimates of the impact of common modifiable risk factors on mortality remain crucial.
Unlocking the Potential: Amino Acids’ Role in Predicting and Exploring Therapeutic Avenues for Type 2 Diabetes Mellitus
1. Introduction Diabetes mellitus is a prevalent chronic metabolic disorder characterized by disrupted glucose homeostasis resulting in hyperglycemia [1]. It can be attributed to the progressive impairment of pancreatic beta cell function or the development of insulin resistance, leading to inadequate insulin action [2,3].
Plasma protein biomarkers trailblaze as early predictors of type 1 diabetes
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Association of Spousal Diabetes Status and Ideal Cardiovascular Health Metrics With Risk of Incident Diabetes Among Chinese Adults
Key Points Question Is there an association between spousal diabetes status, ideal cardiovascular health metrics, and incident diabetes? Findings In this cohort study with 34 821 Chinese adults, spousal diabetes status with uncontrolled glycated hemoglobin level was independently associated with increased risk of incident diabetes. Achievement of ideal cardiovascular health metrics attenuated this risk.
Cardiovascular Risk Based on ASCVD and KDIGO Categories in Chinese Adults: A Nationwide, Population-Based, Prospective Cohort Study
Clinical Epidemiology You have accessRestricted Access Yu Xu, Mian Li, Guijun Qin, Jieli Lu, Li Yan, Min Xu, Tiange Wang, Zhiyun Zhao, Meng Dai, Di Zhang, Qin Wan, Yanan Huo, Lulu Chen, Lixin Shi, Ruying Hu, Xulei Tang, Qing Su, Xuefeng Yu, Yingfen Qin, Gang Chen, Zhengnan Gao, Guixia Wang, Feixia Shen, Zuojie Luo, Li Chen, Yuhong Chen, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Qiang Li, Yufang Bi, Jiajun Zhao, Yiming Mu, Weiqing Wang, Guang Ning and for the China...
Cardiovascular Risk Based on ASCVD and KDIGO Categories in Chinese Adults: A Nationwide, Population-Based, Prospective Cohort Study
Clinical Epidemiology You have accessRestricted Access Yu Xu, Mian Li, Guijun Qin, Jieli Lu, Li Yan, Min Xu, Tiange Wang, Zhiyun Zhao, Meng Dai, Di Zhang, Qin Wan, Yanan Huo, Lulu Chen, Lixin Shi, Ruying Hu, Xulei Tang, Qing Su, Xuefeng Yu, Yingfen Qin, Gang Chen, Zhengnan Gao, Guixia Wang, Feixia Shen, Zuojie Luo, Li Chen, Yuhong Chen, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Qiang Li, Yufang Bi, Jiajun Zhao, Yiming Mu, Weiqing Wang, Guang Ning and for the China...
Association of Serum Bile Acids Profile and Pathway Dysregulation With the Risk of Developing Diabetes Among Normoglycemic Chinese Adults: Findings From the 4C Study
Pathophysiology/Complications Abstract OBJECTIVE Comprehensive assessment of serum bile acids (BAs) aberrations before diabetes onset remains inconclusive. We examined the association of serum BA profile and coregulation with the risk of developing type 2 diabetes mellitus (T2DM) among normoglycemic Chinese adults.
Early Life Famine Exposure, Ideal Cardiovascular Health Metrics, and Risk of Incident Diabetes: Findings From the 4C Study
Cardiovascular and Metabolic Risk Abstract OBJECTIVE We aim to investigate the impact of ideal cardiovascular health metrics (ICVHMs) on the association between famine exposure and adulthood diabetes risk. RESEARCH DESIGN AND METHODS This study included 77,925 participants from the China Cardiometabolic Disease and Cancer Cohort (4C) Study who were born around the time of the Chinese Great Famine and free of diabetes at baseline.
Association of insulin resistance and β-cell dysfunction with incident diabetes among adults in China: a nationwide, population-based, prospective cohort study
Summary Background National investigations on the interaction of insulin resistance, β-cell dysfunction, and obesity with the development of diabetes are scarce in China. We aimed to investigate the individual and joint associations of insulin resistance and β-cell dysfunction with incident diabetes, and to examine the modifying effect of BMI and waist circumference on these associations among adults with normal glucose tolerance and with prediabetes.
High-Coverage Targeted Lipidomics Reveals Novel Serum Lipid Predictors and Lipid Pathway Dysregulation Antecedent to Type 2 Diabetes Onset in Normoglycemic Chinese Adults
Pathophysiology/Complications Abstract OBJECTIVE Comprehensive assessment of serum lipidomic aberrations before type 2 diabetes mellitus (T2DM) onset has remained lacking in Han Chinese. We evaluated changes in lipid coregulation antecedent to T2DM and identified novel lipid predictors for T2DM in individuals with normal glucose regulation (NGR).
Predictive Value of Fasting Glucose, Postload Glucose, and Hemoglobin A1c on Risk of Diabetes and Complications in Chinese Adults
Cardiovascular and Metabolic Risk Abstract OBJECTIVE Uncertainty remains regarding the predictive value of various glycemic measures as they relate to the risk of diabetes and its complications. Using the cutoffs recommended by the American Diabetes Association’s 2010 criteria, we determined the associations of fasting plasma glucose (FPG), 2-h postload glucose (2h-PG), and HbA1c with the outcomes.
Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study
Methods and Results This study investigated the association of estimated glomerular filtration rate (eGFR) with prevalent CVDs, 10‐year Framingham risk for coronary heart disease (CHD), and 10‐year risk of atherosclerotic cardiovascular diseases (ASCVD) in 239 832 participants from the baseline of the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study.
Curbing the obesity epidemic in China
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. In the past few decades, obesity has become a major public health concern worldwide.
Awareness, treatment and control of cardiometabolic disorders in Chinese adults with diabetes: a national representative population study
The China Noncommunicable Disease Surveillance 2010 included 162 study sites, based on the Chinese Center for Disease Control and Prevention’s National Disease Surveillance Point System, which guaranteed a nationally representative sample of the general population, covering major geographic areas of all 31 provinces, autonomous regions, and municipalities in mainland China [12],[18]. The Surveillance Point System includes approximately 1% of the total Chinese population [18].
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