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Jieliu Li on Muck Rack

Jieliu Li

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Articles

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

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By Yao Wen, Xinhui Zheng, Minyu He, Jieliu Li
| Wiley Online Library Verified
1 Introduction The global diabetes mellitus (DM) epidemic, primarily driven by population aging and obesogenic lifestyles, has elevated bone fragility fractures to a major diabetic complication [1, 2]. Clinical analyses confirm a 5 fold increased fracture risk in diabetic cohorts compared to age-matched controls, attributed to impaired osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) and pathological marrow niche remodeling [3, 4].
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