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Brain border‐derived CXCL2+ neutrophils drive NET formation and impair vascular reperfusion following ischemic stroke
1 INTRODUCTION Immune cells capable of interacting with brain-resident cells at the border of the central nervous system (CNS) play a key role in shaping neuroimmune responses and leading to neurodegenerative diseases.1, 2 Recently, accumulating evidence suggests that niches bordering the brain (including the skull, meninges) are the parenchymal myeloid cell reservoirs of the CNS.3 Following brain injury and neuroinflammation, channels between the skull bone marrow and meninges allow myeloid...
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