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Jieqian He

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USP15, activated by TFAP4 transcriptionally, stabilizes SHC1 via deubiquitination and deteriorates renal cell carcinoma

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By Yaxing Shi, Jiaxing Li, Jieqian He
| Wiley Online Library Verified
1 INTRODUCTION Affecting more than 400,000 individuals worldwide annually, renal cell carcinoma (RCC) is the third most common urologic malignancy in developed regions.1 Based on histopathological differences, RCC is divided into three major subtypes: clear cell RCC (ccRCC), papillary renal cell carcinoma (pRCC), and chromophobe renal cell carcinoma (chRCC).2 It is worth noting that more than 70% of patients are diagnosed with the ccRCC subtype, while 15% are pRCC and 5% are chRCC.
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