Jieti Wang

Abstract The epithelial-mesenchymal axis frames gastric cancer heterogeneity but mainly captures phenotypic extremes. CCNE1 gain, encompassing amplification or Cyclin E1 overexpression, represents one intermediate state linked to chromosomal instability and therapeutic resistance. However, its clinicopathologic identity and immune features in gastric cancer remain insufficiently characterised.

ACT adjuvant chemotherapy CIN chromosomal instability EBV Epstein–Barr virus–positive FFPE formalin-fixed and paraffin-embedded F-TBRS pan-fibroblast transforming growth factor-β response signature GC gastric cancer GS genomically stable GSVA gene set variation analysis ICIs immune checkpoint inhibitors IHC immunohistochemistry MMR mismatch repair MSI microsatellite instability NCCN National Comprehensive Cancer Network OS overall survival ssGSEA single-sample gene set enrichment analysis...

The first two authors contributed equally to this article. The last four authors share co-corresponding authorship. J, Gu Y, Zhang Z, et al. Poor clinical outcomes and immunoevasive contexture in gastric cancer patients bearing p16 high phenotype. Cancer. 2026;e70363. doi: Wang 10.1002/cncr.70363 CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. DATA AVAILABILITY STATEMENT Data and materials generated that are relevant to the results are included in this article.