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Jieying Chi on Muck Rack

Jieying Chi

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Articles

A programmable ribozyme for RNA signal transduction - Nature Communications

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By Louis DeFalco, Roland Huber, Jieying Chi
| Nature Verified
Abstract RNA detection applications can be augmented if a sensed RNA can be directly functionally transduced. However, there is no generalisable approach that allows an RNA trigger itself to directly activate diverse non-coding RNA effectors. Here, we report engineering of a programmable, RNA trigger-activated, dual-site self-cleaving ribozyme with modular sensing domain and cleavage product. This platform, UNlocked by Activating RNA (UNBAR), is entirely encoded within one RNA strand.
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