Jieying Liang

1 Introduction Multi-enzyme cascade reactions, wherein multiple enzymes work sequentially to catalyze a series of biochemical transformations,[1] are essential in nature and have significant applications in industrial biocatalysis,[2] medicine and chemical synthesis.[3] These reactions offer advantages such as substrate channeling, reduced by-product formation, and enhanced reaction efficiency.[4] However, the direct use of free enzymes in cascade systems often suffers from issues such as...

One-Pot Spatial Engineering of Multi-Enzyme in Metal-Organic Frameworks for Enhanced Cascade Activity Enzyme encapsulation in metal-organic frameworks (MOFs) faces significant challenges, including restricted substrate diffusion, random enzyme distribution, and diminished catalytic performance, particularly in multi-enzyme systems.

Covalent-Organic Framework Nanobionics for Robust Cytoprotection We present a novel study introducing a durable and robust covalent-organic framework (COF) nanocoating, developed in situ on living cells. This COF nanocoating demonstrates remarkable resistance against a diverse range of lethal stressors, including high temperature, extreme pH, ultraviolet radiation, toxic metal ions, organic pollutants, and strong oxidative stress.