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Jieying Lin on Muck Rack

Jieying Lin

As seen in: Wiley Online Library, ACS Publications, Royal Society of Chemistry
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Articles

Discovery of a Potent RXRγ Degrader WCF-598 for the Treatment of Castration-Resistant Prostate Cancer Click to copy article link Article link copied!

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By Chaofan Wang, Jieying Lin, Junping Pei
| dx.doi.org
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Structure-Based Design of 4-(1-Methyl-1H-indol-3-yl)pyrimidin-2-amine Derivatives as the First Covalent FGFR3 Selective Inhibitors

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By Wenjian Zhu, Xiaojuan Chen, Xiaofei Li, Jieying Lin
| dx.doi.org
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Design, Synthesis, and Biological Evaluation of the First Novel Macrocycle-Based FGFR Inhibitors That Overcome Clinically Acquired Resistance

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By Shuang Xiang, Xiaojuan Chen, Jieying Lin, Xiaojing Lin
| ACS Publications
Abstract Click to copy section linkSection link copied! Alterations in the FGFR family act as oncogenic drivers for multiple pediatric and adult tumors, leading to the development and approval of several FGFR inhibitors. However, the on-target gatekeeper and “molecular brake” mutations confer clinically acquired resistance to the FDA-approved FGFR inhibitors, which presents a significant unmet medical need.
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