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Jill Bargonetti on Muck Rack

Jill Bargonetti

As seen in: Nature
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Articles

Lipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylation - Nature Communications

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By Jill Bargonetti, Subhajyoti De, Wenwei Hu
| Nature Verified
Abstract The tumor-suppressive function of p53 is frequently disrupted by mutations in cancers. Missense mutant p53 (mutp53) protein often stabilizes and accumulates to high levels in cancers to promote tumorigenesis through the gain-of-function (GOF) mechanism. Currently, the mechanism of mutp53 accumulation and GOF is incompletely understood. Here, we identify the lipogenic enzyme FASN as an important regulator of mutp53 accumulation and GOF.
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p53 suppresses MHC class II presentation by intestinal epithelium to protect against radiation-induced gastrointestinal syndrome - Nature Communications

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By Chun-Yuan Chang, Lanjing Zhang, Ping Xie, Zhaohui Feng, Jill Bargonetti
| Nature Verified
Abstract Radiation-induced gastrointestinal syndrome is a major complication and limiting factor for radiotherapy. Tumor suppressor p53 has a protective role in radiation-induced gastrointestinal toxicity. However, its underlying mechanism remains unclear. Here we report that regulating the IL12-p40/MHC class II signaling pathway is a critical mechanism by which p53 protects against radiation-induced gastrointestinal syndrome.
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