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Jill Rocchetti on Muck Rack

Jill Rocchetti

As seen in: BioRxiv
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Articles

Persistent extrasynaptic hyperdopaminergia in the mouse hippocampus induces plasticity and recognition memory deficits reversed by the atypical antipsychotic sulpiride (pdf) | Paperity

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By Jill Rocchetti, Caroline Fasano, Gregory Dal-Bo, Elisa Guma
| paperity.org
PLOS ONE, Aug 2023 Evidence suggests that subcortical hyperdopaminergia alters cognitive function in schizophrenia and antipsychotic drugs (APD) fail at rescuing cognitive deficits in patients. In a previous study, we showed that blocking D2 dopamine receptors (D2R), a core action of APD, led to profound reshaping of mesohippocampal fibers, deficits in synaptic transmission and impairments in learning and memory in the mouse hippocampus (HP).
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Persistent Extrasynaptic Hyperdopaminergia in the mouse Hippocampus Induces Plasticity and Recognition Memory Deficits Reversed by Antipsychotics

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By Elisa Guma, Jill Rocchetti, Caroline Fasano, Gregory Dal-Bo
| BioRxiv
New Results doi: https://doi.org/10.1101/2023.01.12.523788 Abstract Evidence suggests that subcortical hyperdopaminergia alters cognitive function in schizophrenia and antipsychotic drugs (APD) fail at rescuing cognitive deficits in patients. In a previous study, we showed that blocking D2 dopamine receptors (D2R), a core action of APD, led to profound reshaping of mesohippocampal fibers, deficits in synaptic transmission and impairments in learning and memory in the mouse hippocampus (HP).
Open in Who Shared Issue with article?
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