Loading the Elevenlabs Text to Speech AudioNative Player... Key takeaways: The first drug for IgA nephropathy was approved in 2021, and several more are in the pipeline. A public-private partnership worked to redefine surrogate endpoints that made clinical trials feasible. In December 2021, the FDA approved the first therapy indicated to treat primary immunoglobulin A nephropathy. Since then, several novel drugs have received accelerated approval for the disease, and more are in the pipeline.