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Jillian L. Barlow on Muck Rack

Jillian L. Barlow

As seen in: Nature
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Articles

Prospective isolation of mouse and human hematopoietic stem cells using PLXDC2

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By Yosuke Tanaka, Yasushi Kubota, Tomohiro Yabushita, Takaharu Kimura, Ivo Lieberam, Jillian L. Barlow, Tsuyoshi Fukushima, Chiaki Sakuma, Takashi Shibata, Masataka Nakagawa, Yasunori Kurosawa, Toshiaki Maruyama, C. J. Okumura, Yuichiro Arima, Yoshinori Sato, Yasuo Ono, Teruo Akuta, Hidenobu Mizuno, Thomas M. Jessell, Susumu Goyama, Hidekazu Nishikii, Shinya Kimura, Satoshi Yamazaki, Toshio Suda, Toshio Kitamura, Riko Kikuchi, Josh W. Bramley
| Nature Verified
Abstract Numerous strategies exist to isolate hematopoietic stem cells (HSCs) using complex combinations of markers and flow cytometry. However, robust identification of HSCs using imaging techniques is substantially more challenging which has prompted the recent development of HSC reporter mice. To date, very few molecules used in these reporters have been useful for human HSC identification.
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RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus

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By Paula Clark, Alastair Crisp, Jillian L. Barlow
| Nature Verified
Abstract Type 2 innate lymphoid cells (ILC2) contribute to immune homeostasis, protective immunity and tissue repair. Here we demonstrate that functional ILC2 cells can arise in the embryonic thymus from shared T cell precursors, preceding the emergence of CD4+CD8+ (double-positive) T cells. Thymic ILC2 cells migrated to mucosal tissues, with colonization of the intestinal lamina propria.
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