Published: March 25, 2026 at 5:07 PM Sign up for our Newsletters Florida Gov. Ron DeSantis, center, holds a Burmese python at a media event, Thursday, June 16, 2022, where he announced that registration for the 2022 Florida Python Challenge has opened for the annual 10-day event to be held Aug 5-14, , in Miami. The Python Challenge is intended to engage the public in participating in Everglades conservation through invasive species removal of the Burmese python.