Jimena Castorena on Muck Rack

Jimena Castorena

As seen in: Nature
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Articles

PERK orchestrates an endoplasmic reticulum stress alternative splicing program via CLK1/SRSF1

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By Céline Philippe, Arantxa Carrasco-Leon, Andrea Martisova, Pedro Casado, Eleni Maniati, Pantelitsa Protopapa, Alyssa D Fronk, Vinothini Rajeeve, Martin Dodel, Beatriz Galvão, Marc Aubry, Kaliya Georgieva, Doriana Di Bella, Brian N. Papas, Taylor Floyd, Kendall Anderson, Martin Akerman, Jun Wang, Lovorka Stojic, Faraz Mardakheh, Marcos Morgan, Eric Chevet, Christian Touriol, Pedro R. Cutillas, Kevin Rouault-Pierre, Shoshana Burke, Jimena Castorena, Ru-Pin Alicia Chi, Rachel Boniface
| Nature Verified
Abstract The unfolded protein response (UPR) is a critical adaptive program triggered upon cellular stresses that profoundly reshapes the transcriptome and translatome. In the very first minutes of cellular stress, translation blockage, RNA decay and RNA granules formation prompt the synthesis of proteins essential to the stress response.
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