Jimmy Lu

Abstract With the rise in antimicrobial resistance, understanding the virulence factors utilized by pathogenic E. coli is essential for the development of alternative therapeutics. While previous work has shown that disruption of the E. coli rhomboid protease gene glpG leads to defects in bacterial colonization, here we provide mechanistic insight into the loss of fitness. We show GlpG is essential for the assembly of type 1 pili, a virulence factor required for the colonization of eukaryotic cells.

What the research is: Kangaroo is a new flash cache that enables more efficient caching of tiny objects (objects that are ~100 bytes or less) and overcomes the challenges presented by existing flash cache designs. Since Kangaroo is implemented within CacheLib, Facebook’s open source caching engine, developers can use Kangaroo through CacheLib’s API to build their own customized cache services. We partnered with Carnegie Mellon University (CMU) on this research.

Cesar Gonzalez de Alba1* Mehdi H. Moghari2,3 Lorna P. Browne2,3 Richard M. Friesen1 Brian Fonseca1 LaDonna J.