Jin Pak

Loading metrics Open Access Peer-reviewed Research Article Citation: Giannakopoulos S, Pak J, Bakse J, Ward MA, Nerurkar VR, Tallquist MD, et al. (2025) SARS-CoV-2-induced cytokine storm drives prolonged testicular injury and functional impairment in mice that are mitigated by dexamethasone. PLoS Pathog 21(1): e1012804.

To the Editor, Almost 10%–30% of coronavirus disease 2019 (COVID-19) survivors experience several lingering pulmonary complications, including dyspnea, chronic cough, and pulmonary fibrosis after initial recovery, known as long COVID or postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PASC).1 The pathogenesis of PASC is complex and multifactorial, and underlying mechanisms, specifically, the characterization of immune dysregulation, and whether the...

Abstract Compromised male reproductive health is one of the symptoms of long COVID with a decrease in male fertility markers including testosterone levels and sperm count for months in recovering patients. However, the long-term impact of SARS-CoV-2 infection on testicular injury and underlying mechanisms remains unknown. We previously demonstrated a disrupted tissue architecture with no evidence of virus replication in the testis during the acute stage of the disease in K18-hACE2 mice.