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Jindpreet Kandola on Muck Rack

Jindpreet Kandola

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Articles

BRD4 recruitment into HP1 condensates desilences transcription without erasure of repressive chromatin

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By Christopher Brandon, Sarah Robinson-Thiewes, Wojciech Rosikiewicz, Matthew J. Cuneo, Joseph Brett, Walter Lang, Jonathan Low, Ashraf Mohammed, Adithi Danda, Sam Rider Verified, Jason Ochoada, Brandon Young, Theresa Nguyen, Aaron Taylor, Burkhard Hoeckendorf, Patrick Rodrigues, Wenwei Lin, Khaled Khairy, Beisi Xu, Anang A. Shelat, Taosheng Chen, Tanja Mittag, Aseem Z. Ansari, Mangesh Kaulage, Jindpreet Kandola, Marcus Valentine, Sandra J. Kietlinska
| Nature Verified
Abstract How genes are desilenced without erasure of repressive chromatin is a poorly understood phenomenon. A dominant mode of repression occurs through methylation of lysine 9 of histone H3 (H3K9me3), a mark that engages heterochromatin protein 1 (HP1) to drive chromatin compaction and transcriptional silencing. The erasure and replacement of this repressive mark with acetyl/acyl groups recruits positive factors such as BRD4/BET to elicit gene transcription.
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