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Articles by Jing Cen
The burden of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis and its attributable risk factors in 204 countries and territories, 1990–2021
Abstract Objective: Anti-tuberculosis drug resistance has become a major challenge to global tuberculosis control. This study aims to comprehensively the global burden, trends, and risks for disease deaths of multidrug-resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB), HIV/AIDS-MDR-TB, and HIV/AIDS-XDR-TB from 1990 to 2021. Methods: Data on the incidence and deaths of MDR-TB, XDR-TB, HIV/AIDS-MDR-TB, and HIV/AIDS-XDR-TB were obtained from GBD 2021.
The burden of bacterial antimicrobial resistance in the South Asia and high-income Asia-Pacific region over three decades: a systematic analysis
Abstract Background: Antimicrobial resistance (AMR) is an escalating global public health crisis, yet regional disparities remain poorly characterized. This study systematically assessed AMR burden in South Asia and High-income Asia-Pacific (1990–2021) to inform targeted control strategies. Methods: We analyzed data from the Global Burden of Antimicrobial Resistance Study 2021, which serves as the most advanced and current database for assessing the burden of AMR.
The Welander TIA1 mutation dedifferentiates insulin-producing cells - reversal by a GLP-1 receptor agonist
Key words beta cell dedifferentiation liraglutide glucagon-like peptide-1 RNA-binding proteins T-cell intracellular antigen 1 Welander distal myopathy Abbreviations BSA (bovine serum albumin) ECAR (extracellular acidification rate) ER (endoplasmic reticulum) FPKM (fragments per kilobase of exon model per million reads mapped) G3BP1 (G3BP stress granule assembly factor 1) GLP-1 (glucagon-like peptide-1) MOI (multiplicity of infection) Mut (mutated) OCR (oxygen consumption rate) PC1/3...
IJMS | Free Full-Text | GDF15 Protects Insulin-Producing Beta Cells against Pro-Inflammatory Cytokines and Metabolic Stress via Increased Deamination of Intracellular Adenosine
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Ex vivo factor VIII‐modified proliferating human hepatocytes therapy for haemophilia A
Statistical analyses The number of biological and technical replicates and animals are indicated in figure legends and text. All data are presented as the mean ± SD. For most statistic evaluation, an unpaired Student's t test was applied for calculating statistical probability in this study. p Values were calculated by two-tailed test. Only for survival analysis in Figure 5B,G, the Mantel-Cox log-rank test was applied. Statistic calculation was performed using GraphPad Prism9 (GraphPad).
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