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Abstract Background: An effective and safe treatment for nausea and vomiting of pregnancy (NVP) is lacking. Objective: To assess the efficacy and safety of acupuncture, doxylamine–pyridoxine, and a combination of both in women with moderate to severe NVP. Design: Multicenter, randomized, double-blind, placebo-controlled, 2 × 2 factorial trial. (ClinicalTrials.gov: NCT04401384) Setting: 13 tertiary hospitals in mainland China from 21 June 2020 to 2 February 2022.
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