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Jing-yao Li on Muck Rack

Jing-yao Li

As seen in: Frontiers in Immunology
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Articles

Systematic optimization of PD-L1 and CLDN18.2 CAR-T designs identifies a bicistronic dual-target, double-CD3ζ architecture with enhanced antitumor activity in gastric cancer

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By Xiang Zhang, Heng-Hui Li, Liang Chen, Yao-jie Kong, Jing-yao Li
| Frontiers in Immunology
Abstract Background: Gastric cancer is a leading cause of cancer-related mortality, with limited efficacy of immunotherapies due to intratumoral heterogeneity, an immunosuppressive microenvironment, and antigen-loss escape. The optimization of chimeric antigen receptor (CAR) T-cell therapy targeting PD-L1 and Claudin18.2 (CLDN18.2) is crucial for improving the antitumor response.
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