Jinhua Huo on Muck Rack

Jinhua Huo

As seen in: Science Magazine
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Articles

A causal coding variant regulating alternative splicing of DOC2A at 16p.11.2 GWAS locus influences susceptibility to schizophrenia

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By Lianqiang Peng, Emmanuel Cazottes, Danyang Zhou, Yue Zhang, Zhihui Yang, Chuyi Zhang, Qing Zhang, Yong Wu, Hong Chang, Chuang Wang, Xiao Xiao, Xin Cai, Ming Li, Jinhua Huo, Kesi Cui
| Science Magazine
Abstract Although genome-wide association studies (GWASs) have identified many schizophrenia-associated variants, their biological mechanisms remain unclear. Using transcriptomic data from human brain tissues, we performed splicing quantitative trait locus (sQTL) analyses of schizophrenia-associated single-nucleotide polymorphisms and identified more than 17,000 sQTLs linked to previously unidentified splicing junctions.
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