Jinkil Jeong on Muck Rack

Jinkil Jeong

As seen in: Nature
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Articles

Cyclin E1 overexpression identifies a therapeutically relevant poor prognostic patient subgroup in high-grade serous ovarian cancer

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By Mona A. Abed, Jianhui Ma, Divya Rajendran, James L. Yen, Alexandra Levy, Elisa Yaniz-Galende, Félix Blanc-Durand, Christophe Desauw, Philippe Follana, Stéphane Oudard, Véronique D’Hondt, Joyce Liu, Fiona Simpkins, Leslie M. Randall, Alexandra Leary, Mark R. Lackner, Olivier Harismendy, Doris Kim, Heekyung Chung, Nandini Molden, Changhwan Shim, Jinkil Jeong, Nathalie Bonichon-Lamichhane, Céline Gavoille, Danielle D. Jandial
| Nature
Abstract Cyclin-E1 protein overexpression, including through CCNE1 gene amplification, is recognized as a poor prognostic factor in high-grade serous ovarian cancer (HGSOC) and is a promising predictive marker for investigational therapies targeting cell-cycle checkpoints. However, the demonstration of its clinical utility remains elusive due to inconsistent definitions of protein overexpression and gene amplification.
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