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Keywords Aging SARS-CoV-2 hybrid immunity memory B cells circulating T follicular helper cells TEMRA cells CD8⁺ T cells Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has transitioned from a pandemic threat to an endemic respiratory pathogen, with global immunity now shaped by repeated vaccination, natural infection, or their combination.
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide, and it can progress to cirrhosis and hepatocellular carcinoma (HCC). Genetic susceptibility, the gut microbiota, changes in hepatic metabolic pathways, the regulation of lipid metabolism pathways, cellular interactions in the liver, and epigenetic modifications all significantly contribute to MASLD pathogenesis.
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