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Shengxia Yin

As seen in: Nature, Wiley Online Library, Taylor & Francis Online, Journal of Infection, Clinical Microbiology and Infection
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Articles

Age-associated impairment of humoral and cellular immune responses to SARS-CoV-2 in a large community cohort with hybrid immunity

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By Jinqiu Ran, Liguo Zhu, Mingzhe Ning, Wanying Zhang, Wen Zhang, Pei Liu, Shengxia Yin, Juan Zhang, Yuanfang Qin, Ye Wei, Qun Cai, Chentao Guo, Cheng Qian, Jianfei Gao, Fang Zhang, Xin Tong, Chao Wu, Rui Huang, Yuxin Chen, Jinjin Chu, Wenwen Pu
| Journal of Infection Verified
Keywords Aging SARS-CoV-2 hybrid immunity memory B cells circulating T follicular helper cells TEMRA cells CD8⁺ T cells Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has transitioned from a pandemic threat to an endemic respiratory pathogen, with global immunity now shaped by repeated vaccination, natural infection, or their combination.
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The role of hepatocyte epigenetics in the pathogenesis of metabolic dysfunction-associated steatotic liver disease

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By Guangqi Zhu, Qianwen Zhao, Huan Zhang, Shengxia Yin, Junping Shi, Chao Wu, Jie Li, Jinqiu Ran, Rahma Issa
| Nature Verified
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide, and it can progress to cirrhosis and hepatocellular carcinoma (HCC). Genetic susceptibility, the gut microbiota, changes in hepatic metabolic pathways, the regulation of lipid metabolism pathways, cellular interactions in the liver, and epigenetic modifications all significantly contribute to MASLD pathogenesis.
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Age-associated differences in XBB.1.5 trivalent booster vaccine-induced adaptive responses revealed by single-cell RNA sequencing

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By Shixing Chen, Tao Liu, JING CHEN, Shengxia Yin
| Taylor & Francis Online
Abstract Older adults remain highly vulnerable to severe SARS-CoV-2 outcomes despite multiple vaccinations, yet age-associated differences in immune responses to updated COVID-19 booster vaccines remain incompletely characterized. Here, we administered an XBB.1.5 trivalent recombinant protein booster (WSK-V102C) to 22 individuals (<38 years) and 20 individuals (≥73 years), all of whom had previously received 2-3 doses of inactivated COVID-19 vaccines.
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